ZINC4228257 (Kuvan)
| Added | Available | Since | Mwt | logP | Heavy Atoms | Tranche | Download |
|---|---|---|---|---|---|---|---|
| 2005-11-15 | In-Stock | 2015-08-07 | 241.251 | -1.7 | 17 | BAAA |
|
Find Decoys
Available 3D Representations
| pH range | Net charge |
H-bond donors |
H-bond acceptors |
tPSA Ų | Rotatable bonds |
Apolar desolvationkcal/mol |
Polar desolvationkcal/mol |
Download |
|---|---|---|---|---|---|---|---|---|
| Reference | 0 | 6 | 7 | 136 | 2 | -5.39 | -20.06 |
|
| Mid pH (7.4) | 0 | 6 | 7 | 136 | 2 | -4.48 | -13.64 |
|
| High pH (8.4) | -1 | 5 | 7 | 134 | 2 | -5.63 | -47.16 |
|
21 Items Total
Vendors (11 Total)
-
- T19180
-
- DR000574
- HE008003
- HE077491
- HE286267
- HE286290
- HE318798
26 Items Total
Annotated Catalogs (23 Total)
Activities based on ChEMBL 20
There is no known activity for this compound.
Run SEA
SEA Predictions based on ChEMBL 20
| Gene | Description | Target Class | P-Value | Max Tc |
|---|---|---|---|---|
| NOS3 | Nitric oxide synthase, endothelial | enzyme / enzyme-other | 0 | 61 |
Find All
Interesting Analogs
Substance Rings
Molecular Patterns (Warnings, etc.)
References
This substance is not reported in any publications per ChEMBL.
View All 17 Clinical Trials
| Trial ID | Title | Status | Phase | Start Date | Condition(s) | Drug(s) |
|---|---|---|---|---|---|---|
| NCT00432822 | Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and Safety | Terminated | Phase 2/Phase 3 | Unknown |
Phenylalanine Hydroxylase Deficiencies
|
tetrahydrobiopterin (BH4)
|
| NCT02042196 | Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women | Recruiting | Phase 0 | Dec 2013 |
Menopause
Aging
|
KUVAN
Placebo
Cetrotide
Climara
Placebo transdermal patch
|
| NCT01965912 | Kuvan®'s Effect on the Cognition of Children With Phenylketonuria | Recruiting | Phase 4 | Oct 2013 |
Phenylketonuria
|
Kuvan®
|
| NCT01732471 | Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Subjects With Phenylketonuria | Completed | Phase 3 | Nov 2012 |
Phenylketonuria
|
Kuvan®
|
| NCT01706965 | Kuvan in People With Schizophrenia and Schizoaffective Disorder | Suspended | Phase 1/Phase 2 | Oct 2012 |
Schizophrenia
Schizoaffective Disorder
|
Kuvan
Multivitamin
|