ZINC4228258 (Kuvan)
| Added | Available | Since | Mwt | logP | Heavy Atoms | Tranche | Download |
|---|---|---|---|---|---|---|---|
| 2005-11-15 | In-Stock | 2015-08-07 | 241.251 | -1.7 | 17 | BAAA |
|
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Available 3D Representations
| pH range | Net charge |
H-bond donors |
H-bond acceptors |
tPSA Ų | Rotatable bonds |
Apolar desolvationkcal/mol |
Polar desolvationkcal/mol |
Download |
|---|---|---|---|---|---|---|---|---|
| Reference | -1 | 6 | 7 | 136 | 2 | -5.59 | -43.75 |
|
| Mid pH (7.4) | 0 | 6 | 7 | 136 | 2 | -4.44 | -11.71 |
|
| High pH (8.4) | -1 | 5 | 7 | 134 | 2 | -5.59 | -43.75 |
|
15 Items Total
Vendors (12 Total)
14 Items Total
Annotated Catalogs (13 Total)
Activities based on ChEMBL 20
There is no known activity for this compound.
Run SEA
SEA Predictions based on ChEMBL 20
| Gene | Description | Target Class | P-Value | Max Tc |
|---|---|---|---|---|
| NOS3 | Nitric oxide synthase, endothelial | enzyme / enzyme-other | 0 | 51 |
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Interesting Analogs
Substance Rings
Molecular Patterns (Warnings, etc.)
References
This substance is not reported in any publications per ChEMBL.
View All 17 Clinical Trials
| Trial ID | Title | Status | Phase | Start Date | Condition(s) | Drug(s) |
|---|---|---|---|---|---|---|
| NCT00432822 | Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and Safety | Terminated | Phase 2/Phase 3 | Unknown |
Phenylalanine Hydroxylase Deficiencies
|
tetrahydrobiopterin (BH4)
|
| NCT02042196 | Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women | Recruiting | Phase 0 | Dec 2013 |
Menopause
Aging
|
KUVAN
Placebo
Cetrotide
Climara
Placebo transdermal patch
|
| NCT01965912 | Kuvan®'s Effect on the Cognition of Children With Phenylketonuria | Recruiting | Phase 4 | Oct 2013 |
Phenylketonuria
|
Kuvan®
|
| NCT01732471 | Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Subjects With Phenylketonuria | Completed | Phase 3 | Nov 2012 |
Phenylketonuria
|
Kuvan®
|
| NCT01706965 | Kuvan in People With Schizophrenia and Schizoaffective Disorder | Suspended | Phase 1/Phase 2 | Oct 2012 |
Schizophrenia
Schizoaffective Disorder
|
Kuvan
Multivitamin
|